I-Keto kunye neGout: Ngaba i-Keto Diet inokunceda iimpawu zeGout?

Ukuba utya inyama, intlanzi, okanye inyama yenyama, unokuzibuza: ngaba oku kutya kwe-keto-friendly kwandisa umngcipheko wokuphuhlisa i-gout?

Emva kwayo yonke loo nto, ubulumko obuqhelekileyo bubambe ukuba iprotheyini ephezulu kunye nokutya okunamafutha aphezulu kusemva kohlaselo lwegout.

Nangona kukho ingqiqo emva kwale ngcamango, kukho uphando oluncinci kakhulu lokuxhasa ikhonkco phakathi kweprotheni yezilwanyana, ukutya okunamafutha aphezulu, kunye nomngcipheko wegout.

Nangona kunjalo, kukho abanye oonobangela begawuthi, kwaye ukutya ukutya okukumgangatho ophezulu yenye yezona ndlela zibalaseleyo zokuthintela okanye ukuthomalalisa igawuthi.

Yintoni igawuthi?

I-Gout luhlobo lwesifo samathambo esibangelwa kukwakhiwa okubuhlungu kweekristale ze-uric acid kumalungu, imisipha, kunye nemilenze, ngakumbi amalungu ezandla kunye neenzwane ezinkulu.

Iikristale ze-uric acid zenza xa amanqanaba egazi e-uric acid efikelela kumazinga aphezulu ngokungaqhelekanga. Le meko ibizwa ngokuba yi-hyperuricemia, kwaye sesona siphawuli somngcipheko wegawuthi.

Nangona kunjalo, kubalulekile ukuqaphela ukuba i-gaut inqabile: kuphela i-5% yabantu abane-uric acid engaphezulu kwe-9 mg/dL (ithathwa njenge-hyperuricemia) ikhula gaut.

Kwiminyaka emininzi edlulileyo, i-gout yaziwa ngokuba "isifo sookumkani" kunye "nesifo sesityebi." Kuyavela ukuba abantu abazizityebi yayikuphela kwabantu ababenakho ukuthenga iswekile, ngoku ebhalwe kakuhle umngcipheko wegout.

I-Gout ichaphazela malunga ne-1-4% yabemi (i-3-6% yamadoda kunye ne-1-2% yabasetyhini). Ehlabathini lonke, ukuxhaphaka kwegawuthi kuye kwanda, ekusenokwenzeka ukuba kungenxa yokuwohloka kweendlela zokutya, ukungazilolongi, nokunyuka kwamazinga okutyeba ngokugqithiseleyo nesifo semetabolism. Kukwabonakala kukho icandelo lemfuzo kumngcipheko wegout ( ¹ ).

Ukunyanga igawuthi, oogqirha bahlala benika amayeza axubileyo anciphisa ukuveliswa kwe-uric acid, okanye bacebise ukutya okuneprotheyini encinci. Kodwa uphando olutsha lukhanyisela oonobangela begawuthi, kwaye kuya kucaca ukuba kukho iindlela ezingcono kunokusika iprotein ukukhupha igawuthi.

Yintoni ebangela igawuthi?

I-Gout iyenzeka xa iikristale ze-uric acid zenzekile ngenxa ye-uric acid eninzi egazini, yakheka kwizicubu ezixhumeneyo, kwaye ibangele iintlungu, ukudumba, ububomvu kunye nokudumba. Ukuphelisa igawuthi, ufuna ukunciphisa imveliso yakho ye-uric acid.

Kukho izinto ezimbalwa ezinokuthi ziqhube ukuveliswa kwe-uric acid:

iprotheni kunye ne-gout

Oogqirha badla ngokucebisa ukutya okuneprotheyini encinci, ukutya okunenyama encinci kwigawuthi.

Ukuqiqa kukuba uninzi lwemithombo yeprotheyini iqulethe iikhompawundi ezibizwa ngokuba zii-purines ezingabaphambili kwi-uric acid.

IiPurines zenza imathiriyeli yemfuza kwi-DNA kunye ne-RNA, kwaye xa usetyisa ii-purines, umzimba wakho uyazophula zibe yi-uric acid. Imithombo ecebileyo ye-purines yinyama, intlanzi kunye nenyama yenyama.

Ithiyori yeyokuba ukunciphisa ukutya kwakho kwe-purine kuya kunciphisa amanqanaba akho e-uric acid kwaye, emva koko, wehlise umngcipheko we-gout.

Nangona kunjalo, isayensi malunga nokusetyenziswa kweprotheyini kunye ne-gout ixutywe.

Ngokomzekelo, uphando oluthile ludibanisa ukusetyenziswa kwenyama kunye nokutya kwaselwandle kumngcipheko okhulayo we-gout ( ² ). Kodwa kuphononongo olulawulwa ngakumbi, abaphandi bafumanisa ukuba iinyanga ezintandathu zeprotheyini ephezulu, ukutya okune-carb ephantsi ngokwenene kwehlisa amanqanaba e-uric acid kwi-74 enzima kakhulu okanye abathathi-nxaxheba abatyebileyo.

Ababhali baphetha ngokuthi "ukutya kwe-Atkins (ukutya okuneprotheyini ephezulu ngaphandle kwesithintelo se-caloric) kunokunciphisa amanqanaba [e-serum uric acid] nangona ukulayisha okukhulu kwe-purine."

Olunye ulwazi lubonisa ukuba i-vegans inamanqanaba aphezulu e-uric acid kunabo batya inyama, icebisa ukuba ngaphezulu kusemngciphekweni kunokuthatha nje iiprotheyini.

Uphando lwakutsha nje lufumanise ukuba xa utya ukutya okuneprotheyini ephezulu, izintso zakho azinangxaki yokukhupha i-uric acid eziyenzayo kwi-purines.

Ngamanye amazwi, ii-purines ezininzi, ngaphezulu kwe-uric acid ngaphandle ( ³ ). Logama nje izintso zakho zisebenza kakuhle, iprotein ayibonakali inyusa umngcipheko wakho wegout.

ubisi kunye negawuthi

Ngenxa yokuba iimveliso zobisi zineprotheyini eninzi (kunye nee-purines), abanye banexhala lokuba ukutya ubisi, itshizi, okanye iyogathi kuya kwandisa umngcipheko wokuba negawuthi.

Kodwa kuphononongo olukhulu olwalandela abantu abangama-47.150 kwiminyaka eyi-12, abaphandi bafumanisa okuchaseneyo: Ukusetyenziswa kobisi kwakunxulumene ngokungafaniyo nomngcipheko wegout. Ngelixa olu phononongo lungabonakalisi sizathu kunye nesiphumo, kubonakala ngathi iimveliso zobisi zicacile xa kuziwa kwigawuthi.

iswekile kunye nethontsi

Iswekile yeyona nto inokuba negalelo kwigawuthi kuneprotein. Ngokukodwa, i-fructose, iswekile eqhelekileyo kwiziqhamo kunye nesiraphu yengqolowa.

I-Fructose yonyusa imveliso ye-uric acid, ngelixa kwangaxeshanye ikhusela ukukhutshwa kwe-uric acid.

Isibindi sakho siqhuba i-fructose ngokwahlukileyo kunezinye iiswekile. Ukuba isibindi sakho silayishwe nge-fructose, sinokuphazamisa iprotheni ye-metabolism kunye nokuphelisa i-ATP (amandla eselula).

Xa i-ATP yakho ihla, imveliso yakho ye-uric acid iyanda ( ⁴ ) - kwaye njengoko ufunde ngaphambili, i-uric acid ephezulu yeyona nto inobungozi kwigawuthi.

Isizathu sesibini sokuphepha i-fructose sibandakanya ukukhutshwa kwe-uric acid. Xa utya i-fructose eninzi ngexesha elide, unciphisa amandla ezintso zakho zokukhupha i-uric acid.

Kodwa ayikuko nje ukusetyenziswa okungapheliyo, nokuba idosi enye ye-fructose yehlisa ukukhutshwa komchamo. ⁵ ).

Umthombo oqhelekileyo we-fructose ekudleni kwanamhlanje yi-fructose ephezulu isiraphu yengqolowa. Uya kuyifumana kuyo yonke into ukusuka kwiziselo ezithambileyo ukuya kwicookies ukuya kwicereal. Yenza inqaku lokuphepha isiraphu yengqolowa ephezulu ye-fructose; uya kuziva ungcono kakhulu ngaphandle kwayo.

i-insulin kunye ne-gout

Iswekile, i-fructose okanye enye into, ikwanyusa umngcipheko we-gout ngokulawula amanqanaba e-insulin.

Xa utya iswekile eninzi, izinga leswekile egazini lakho liyenyuka. Ukuphendula, i-pancreas yakho ikhupha i-insulin, yakho Umlawuli weSwekile yegazi, ukukrazula iswekile egqithisileyo egazini kwaye uyise kwiiseli zakho, apho inokuguqulwa ibe amandla (ukusetyenziswa kwangoko) okanye amanqatha (ukugcina amandla).

Kodwa ukuba utya iswekile eninzi rhoqo, iswekile yegazi lakho ihlala iphezulu, kwaye i-insulin iyayeka ukunxibelelana neeseli zakho ngokufanelekileyo.

Eyaziwa ngokuba yi-insulin resistance (okanye i-metabolic syndrome), le meko ibangela ukuba i-pancreas impompe i-insulin eninzi ukwenza umsebenzi ofanayo.

Amanqanaba aphezulu e-insulin ejikelezayo anciphisa ukucocwa kwe-uric acid ( ⁶ ). Ukugcina i-gout, kufuneka uhlale unomdla kwi-insulin. Eyona ndlela ilungileyo yokwenza oku kukuphelisa iswekile ekutyeni kwakho.

utywala kunye negawuthi

Utywala ngumngcipheko osekwe kakuhle wokuphuhlisa igawuthi, kwaye kwandisa umngcipheko wokuhlaselwa yigawuthi ukuba sele unayo imeko.

Kuphononongo olulindelekileyo, abaphandi balandela amadoda angama-47.150 angenayo imbali ye-gout iminyaka eyi-12. Bafumanise ukuba ukusela ibhiya, kunye ne-spirit encinci, yayinxulunyaniswa ngamandla kwaye ngokuzimeleyo nomngcipheko wegout. Okumangalisayo kukuba, iwayini yayingekho ( ⁷ ).

Elinye iqela labaphandi labuza umbuzo owahlukileyo: Kwabo sele benesifo segawuthi, ukusela utywala kwandisa kangakanani umngcipheko wokuhlaselwa kwegawuthi?

Bafumanise ukuba zonke iintlobo zotywala, kuquka newayini, zanxulunyaniswa nengozi eyongezelelekileyo yokugqabhuka kwegout kwiiyure ezingama-24 zokusela.

Indlela yokuphepha igawuthi

Ukuphepha igawuthi kuhla ekunciphiseni oonobangela ngqa ye-uric acid ephakamileyo edweliswe kwicandelo elingaphambili. Inyama, amafutha, kunye neeprotheyini azibonakali zinegalelo elikhulu kwigawuthi.

Endaweni yoko, nciphisa i-fructose kunye notywala ukuze ugcine amanqanaba e-uric acid enempilo kwaye unciphise umngcipheko we-gout. Kukho i-fructose kwisiqhamo, kodwa owona mthombo we-fructose yi-fructose ephezulu ye-corn isiraphu. Ukuba ufuna ukwenza into enye ukunciphisa umngcipheko wakho we-gout, susa isiraphu yengqolowa ephezulu ye-fructose ekudleni kwakho.

Omnye umngcipheko we-gout, i-metabolic syndrome, idibaniswe nokusetyenziswa kweswekile. Ukuba unesifo se-metabolic syndrome okanye uhlobo lwe-2 yeswekile, iswekile ephezulu yegazi, i-insulin ephezulu, ukutyeba, kunye noxinzelelo lwegazi oluphezulu, unomngcipheko ophezulu we-gout.

Ukulungisa isifo se-metabolic syndrome kunye nokumelana ne-insulin akuyi kwenzeka ngobusuku. Kodwa ukutya okune-carb ephantsi (okufana nokutya kwe-ketogenic) kuye kwaboniswa ukuba kugcinwe iswekile egazini, baphucula ubuntununtunu be-insulin kwaye bavuselele ukwehla kobunzima.

Ukutya kwe-ketogenic yindlela efanelekileyo yokukhusela i-gout.

Uyakufuna kwakhona ukuhlala u-hydrated ukukhusela i-gout. Qinisekisa ukuba usela amanzi aneleyo. Xa uphelelwe ngamanzi emzimbeni, umzimba wakho uyayeka ukukhupha i-uric acid, nto leyo ethetha ukuba iikristale ze-uric acid zinokwenzeka ukuba zenzeke kumalungu akho.

Okokugqibela, amayeza ambalwa, uninzi lwawo i-diuretics anokubangela ukuphelelwa ngamanzi emzimbeni, adityaniswe nomngcipheko wokwanda kwegout. Kwaye abaphandi baye bafumanisa ukuba idosi ephantsi ye-aspirin inokuphazamisa ukusebenza kwezintso kwaye ichaphazele ukukhutshwa kwe-uric acid.

Yintoni omawuyenze xa unegawuthi

Into yokuqala ekufuneka uyenzile ukuba unegawuthi kukubona ugqirha. Unokumisela amayeza abizwa ngokuba yi-xanthine oxidase inhibitors ukunciphisa amanqanaba akho e-uric acid.

Ngaphaya koko, kuya kufuneka ucinge ngotshintsho lwendlela yokuphila, ngakumbi xa kuziwa kukutya kunye nokuzilolonga.

Ukutya ntoni xa unegawuthi

Ukutya okuthile kunye nezongezelelo ziye zaboniswa ukukhusela kwi-gout kwaye zinokunciphisa iimpawu ze-gaut. Ezi ziquka:

• Ivithamin C: Ibangela ukuba izintso zikhuphe i-uric acid eninzi.⁸ ).
• Ioli yomnquma
• Iimveliso zederi.
• Iicherry - zibonakaliswe ukunciphisa i-plasma uric acid kubasetyhini ( ⁹ ).
• Amanzi eminerali: Athintela ukwakheka kweekristale zeuric acid.¹⁰ ).
• Ikofu: Ukusetyenziswa kwekofu ngokuphakathi kunciphisa amanqanaba e-uric acid.¹¹ ).

umthambo kunye negawuthi

Ukongeza kuhlengahlengiso lokutya okungentla, inkqubo yokuzivocavoca rhoqo inokuphinda incede kwi-gout.

Umthambo:

• Yandisa uvakalelo lwe-insulin kwaye inokuphucula i-metabolic syndrome.¹² ).
• Iphelisa i-glycogen yesibindi, equlethe i-uric acid-ekhuthaza i-fructose.
• Ikhusela i-hyperinsulinemia, enokunceda ukucocwa kwe-uric acid ( ¹³ ).

Kuthekani ngokutya kwe-ketogenic ye-gout?

Ngaba ukutya kwe-ketogenic kwandisa umngcipheko wakho we-gout?

Kwiiveki ezimbini zokuqala zokutya kwe-ketogenic, unokubona ukunyuka kwexesha elifutshane kumngcipheko wakho we-gout. Oku kungenxa yokuba amanqanaba aphezulu eeketones athintela izintso zakho ekucoceni ngokufanelekileyo uric acid. [ ¹⁴ ).

Kodwa nazi iindaba ezimnandi: Emva kweeveki ezimbini ukuya kwezintathu, uziqhelanisa ne-keto, kwaye amanqanaba akho e-uric acid abuyela kwimeko yesiqhelo. Inyaniso, kwisidlo se-ketogenic, umngcipheko wexesha elide we-gout (ulinganiswa ngamaqondo e-uric acid) ngokwenene iyancipha ( ¹⁵ ).

Enye into, i-keto igcina amanqanaba akho e-insulin ejonge. Xa unqanda i-carbs kwi-fat-fat ketogenic diet, iswekile yakho yegazi ihlala iphantsi, kwaye xa iswekile yegazi ihlala iphantsi, i-insulin yakho ihlala iphantsi, nayo. I-insulin ephantsi, ukuba uyakhumbula, inceda izintso zakho zikhuphe i-uric acid.

Kukwakho nezinye iindlela ezidlalwayo. Kwisidlo se-ketogenic, isibindi sakho sivelisa i-ketones, kunye ne-beta-hydroxybutyrate (BHB) eyona nto ibalulekileyo.

Kungekudala, iqela labaphandi baseYale bafumanisa ukuba i-bhB yanciphisa umngcipheko we-gout flares kwiigundane. I-BHB inciphisa ukuvuvukala ngokuvimbela inxalenye ye-immune system ebizwa ngokuba yi-NLRP3 inflammasome, enokunciphisa umngcipheko wokuhlaselwa kwe-gout.

I-Keto kunye ne-gout: umgca ophantsi

Izinto ezininzi zonyusa umngcipheko wokukhula kwegawuthi. Ukuphelelwa ngamanzi emzimbeni, i-fructose, ukunganyangeki kwe-insulin, kunye notywala kwandisa i-uric acid, eqhuba ukubunjwa kwekristale kwaye ekugqibeleni igawuthi.

Ukuthintela igawuthi, zithintele ezi zinto zinobungozi kwaye uzame uhlengahlengiso lokutya okufana nokusela ikofu kunye nokuthatha ivithamin C. Kwakhona qwalasela inkqubo yokuzivocavoca rhoqo ukunyusa uvakalelo lwakho lwe-insulin.

Ekugqibeleni, xa kuziwa kumngcipheko we-gout, ungakhathazeki ngokutya amafutha kunye neprotheni. I-Sugar (ingakumbi i-fructose) i-macro ukuphepha Ukutya okuphantsi kwe-carb ketogenic kubonakala kuyisicwangciso esihle sexesha elide lokunciphisa ingozi ye-gout. Ukuze ufunde ngakumbi malunga nokuhamba kwe-keto, jonga yethu Isikhokelo seKeto esisisiseko Kulula ukulandela.